abstract：:Cytopathic bovine viral diarrhoea virus (cp BVDV) induces apoptosis in bovine cell cultures. This also seems to be a prominent feature in the pathogenesis of mucosal disease. To gain an insight into the molecular pathways of the cell alterations, the involvement of different members of the apoptotic cascade was analyz...

journal_title：Virus research

authors： Grummer B,Bendfeldt S,Wagner B,Greiser-Wilke I

更新日期：2002-12-01 00:00:00

abstract：:We have found that an HIV-1 accessory gene product Vpr enhanced HIV-1 reproduction in U1 cells chiefly by the induction of TNF, a proinflammatory cytokine, which was also known to be an activator of HIV-1 reproduction. We have generated the functional HIV-1 accessory gene product Vpr in bacterial cells. Vpr was genera...

journal_title：Virus research

authors： Nakamura T,Suzuki H,Okamoto T,Kotani S,Atsuji Y,Tanaka T,Ito Y

更新日期：2002-12-01 00:00:00

abstract：:The goal of this review is to summarize recently published epidemiological information that contribute to understanding the natural history of cervical and human papillomavirus (HPV) infection and their associated lesions among human immunodeficiency virus (HIV) infected women and men. HIV-positive women and men are m...

journal_title：Virus research

authors： de Sanjosé S,Palefsky J

更新日期：2002-11-01 00:00:00

abstract：:Recent scientific advances are providing an opportunity to revisit strategies for cervical cancer prevention. How to invest health resources wisely, such that clinical benefits are maximized-and opportunity costs are minimized-is a critical question in the setting of new technology. In addition to an intervention's ef...

journal_title：Virus research

authors： Goldie SJ

更新日期：2002-11-01 00:00:00

abstract：:To examine the mechanism of HIV-1 regulation by NF-IL6 in activated human cells, we selected a Jurkat cell line that did not contain endogenous NF-IL6. In this cellular environment, we evaluated the effect of exogenous NF-IL6 on transcription mediated by native and deleted LTR sequences. In Jurkat cells stimulated wit...

journal_title：Virus research

authors： Buckner AE,Tesmer VM,Bina M

更新日期：2002-10-01 00:00:00

abstract：:The nature of the interaction between papillomaviruses (PV) and their infected host has led to the identification of ways in which the viral oncoproteins can transform the infected host cells into cancer cells. As viral persistence is required for malignancy, and persistence requires avoidance of immune attack by the ...

journal_title：Virus research

authors： O'Brien PM,Saveria Campo M

更新日期：2002-09-01 00:00:00

abstract：:Viruses of the genus 'Norwalk-like viruses' (NLVs) detected in humans have been genetically classified into two major genetic groups, genogroups I and II (GI and GII), which together are made up of at least 14 genetic subgroups. However, a comparable classification of NLVs in other species remains to be carried out. W...

journal_title：Virus research

authors： Sugieda M,Nakajima S

更新日期：2002-08-01 00:00:00

abstract：:The broad bean strain of Tobacco mosaic virus (TMV-B) infects Nicotiana tabacum White Burley systemically whereas the tomato strain of T. mosaic virus (ToMV-S1) induces necrotic local lesions and is restricted to inoculated leaves. To examine the possible role of the viral movement protein (MP) in these symptom differ...

journal_title：Virus research

authors： Wu J,Zhou X

更新日期：2002-07-01 00:00:00

abstract：:The entry of herpes simplex virus (HSV) into an oral epithelial cell line, primary normal human oral keratinocytes (NHOK) and gingival fibroblasts (GF) was examined. Infection of these cells by HSV-1 and HSV-2 was blocked by heparin. Further examination indicated that heparin reduced viral attachment but not penetrati...

journal_title：Virus research

authors： Hung SL,Wang YH,Chen HW,Lee PL,Chen YT

更新日期：2002-06-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, belongs to a group of RNA viruses that are cytopathic for macrophages and establish persistent infections. Apoptosis is the presumed mechanism of cell death in monkey kidney cell lines and porcine alveolar macrophages after infection with Eur...

journal_title：Virus research

authors： Kim TS,Benfield DA,Rowland RR

更新日期：2002-05-10 00:00:00

abstract：:Echovirus 18 (EV18) is one of the echovirus serotypes associated with human diseases and in particular aseptic meningitis. To facilitate studies of the molecular epidemiology of EV18 and the evolution of enteroviruses in general, the complete nucleotide (nt) sequence was determined for the echovirus 18 prototype strai...

journal_title：Virus research

authors： Andersson P,Edman K,Lindberg AM

更新日期：2002-04-23 00:00:00

abstract：:Puumala (PUU) virus causes a form of hemorrhagic fever with renal syndrome (HFRS), called nephropathia epidemica (NE), in Europe. HFRS is characterized by an increased capillary permeability, which we hypothesize is caused by hyperactivation of the host immune system, especially cellular immune responses. To identify ...

journal_title：Virus research

authors： Terajima M,Van Epps HL,Li D,Leporati AM,Juhlin SE,Mustonen J,Vaheri A,Ennis FA

更新日期：2002-03-20 00:00:00

abstract：:Murine cytomegalovirus (MCMV) m137 null mutants, Deltam137A and Deltam137B, were generated by inserting a gpt cassette into a deleted region of the open reading frame. A polyclonal antiserum produced to an Escherichia coli expressed gst-m137 fusion protein was used to show that a 38 kDa polypeptide corresponding to th...

journal_title：Virus research

authors： Visalli RJ,Fairhurst J,Kothandaraman S,Buklan A

更新日期：2002-03-20 00:00:00

abstract：:The hemagglutinin (HA) protein of influenza virus binds to terminal sialic acid residues present on cell surface glycoproteins and glycolipids. The specific amino acids involved in this interaction have been identified for a H3 subtype HA from the human non-pathogenic virus, A/Aichi/2/68, by both crystallographic and ...

journal_title：Virus research

authors： Lin AH,Cannon PM

更新日期：2002-02-26 00:00:00

abstract：:Genome segments 1 and 2 of human group C rotavirus 'Bristol' strain were sequenced and their gene-protein coding properties assigned. This work completed the genome sequence of a human group C rotavirus (17,910 bp) and allowed the full gene-protein coding assignment of the 11 segments of dsRNA. Gene 1 is 3309 bp in si...

journal_title：Virus research

authors： Chen Z,Lambden PR,Lau J,Caul EO,Clarke IN

更新日期：2002-02-26 00:00:00

abstract：:The interaction of human adenovirus type 12 (Ad12) with Syrian hamster cells is remarkable in that there is a block of viral DNA replication and late gene transcription. We have screened several cellular factors known to play a role in adenovirus replication for their possible contributions to the interactions of Ad12...

journal_title：Virus research

authors： Hösel M,Schröer J,Webb D,Jaroshevskaja E,Doerfler W

更新日期：2001-12-04 00:00:00

abstract：:The 'infectious DNA' approach, which is based on in vivo transcription of (+)RNA virus genome cDNA cassettes from eukaryotic promoters in transfected cells, became a popular alternative to the classical scheme in the infectious clone methodology. Its use, however, is often limited by the instability of plasmids due to...

journal_title：Virus research

authors： Mishin VP,Cominelli F,Yamshchikov VF

更新日期：2001-12-04 00:00:00

abstract：:The immune response to a naked plasmid DNA encoding the nucleoprotein (N protein) of porcine transmissible gastroenteritis virus (TGEV) was investigated in this study. A complementary DNA of the entire N gene was amplified by RT-PCR, and inserted into a mammalian expression vector (pcDNA3.1) to construct a recombinant...

journal_title：Virus research

authors： Liu C,Kokuho T,Kubota T,Watanabe S,Inumaru S,Yokomizo Y,Onodera T

更新日期：2001-11-28 00:00:00

abstract：:The surface antigen gene region from five chronic hepatitis B virus (HBV) infected chimpanzees was amplified by PCR and the sequence determined. Sequence comparison confirmed that all of the sequences were chimpanzee hepatitis B virus (chHBV) and they appeared to represent three distinct clusters or branches. To addre...

journal_title：Virus research

authors： Hu X,Javadian A,Gagneux P,Robertson BH

更新日期：2001-11-05 00:00:00

abstract：:The human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of a chronic progressive myelopathy (TSP/HAM) in which lesions of the central nervous system (CNS) are associated with infiltration of HTLV-1-infected T-cells. In a model that mimics the interaction between glial and T-cells, we show that transient ...

journal_title：Virus research

authors： Akaoka H,Szymocha R,Beurton-Marduel P,Bernard A,Belin MF,Giraudon P

更新日期：2001-10-30 00:00:00

abstract：:Genetic characterization was conducted on 17 wild-type measles viruses isolated near Hanoi, Vietnam, during 1998 as well as on eight viruses isolated in the Hunan, Hainan, Shandong, and Anhui provinces of the People's Republic of China during 1995, 1998, and 1999. Previous studies had shown that, compared to wild-type...

journal_title：Virus research

authors： Liffick SL,Thi Thoung N,Xu W,Li Y,Phoung Lien H,Bellini WJ,Rota PA

更新日期：2001-09-01 00:00:00

abstract：:To study the process of feline immunodeficiency virus (FIV) assembly, we examined the suitability of the vaccinia vector system to reproduce FIV particle formation. To this end, we constructed a recombinant vaccinia virus carrying the FIV gag gene. Biochemical and electron microscopy analyses of cells infected with th...

journal_title：Virus research

authors： Manrique ML,Celma CC,González SA,Affranchino JL

更新日期：2001-07-01 00:00:00

abstract：:We have recently identified and sequenced a molecular clone of the serogroup 2 simian retrovirus (SRV), D2/RHE/OR/V1, that retains an enhanced ability to infect specific T cell lines. In this report, using deletion mutagenesis, we localized the psi packaging signal, necessary for packaging of D2/RHE/OR/V1 particles, t...

journal_title：Virus research

authors： Li B,Nguyen S,Li X,Machida CA

更新日期：2001-06-01 00:00:00

abstract：:In Canada, hantavirus infected deer mice (Peromyscus maniculatus) have been collected from British Columbia to Newfoundland. Partial sequencing of G1 and N protein encoding regions from Canadian Peromyscus maniculatus-borne hantaviruses demonstrated the existence of significant genotypic divergence among strains. Phyl...

journal_title：Virus research

authors： Drebot MA,Gavrilovskaya I,Mackow ER,Chen Z,Lindsay R,Sanchez AJ,Nichol ST,Artsob H

更新日期：2001-05-01 00:00:00

abstract：:The sequence of the VP7 gene of two rotaviruses isolated from dogs in southern Italy was determined and the inferred amino acid sequence was compared with that of other rotavirus strains. There was very high nucleotide and amino acid identity between canine strain RV198/95 and other canine strains, and to the human st...

journal_title：Virus research

authors： Martella V,Pratelli A,Greco G,Gentile M,Fiorente P,Tempesta M,Buonavoglia C

更新日期：2001-04-01 00:00:00

abstract：:The fidelity of poliovirus RNA-dependent RNA polymerase (3D(pol)) was determined using a system based on the fidelity of synthesis of the alpha-lac gene which codes for a subunit of beta-galactosidase. Synthesis products are screened for mutations by an alpha-complementation assay, in which the protein product from al...

journal_title：Virus research

authors： Wells VR,Plotch SJ,DeStefano JJ

更新日期：2001-04-01 00:00:00

abstract：:We have previously identified an inhibitory, 57 nt AU-rich sequence in the HPV-1 late 3' UTR, termed as the HPV-1 AU-rich element (h1ARE). It contains two types of functionally important motifs: two AUUUA sequences and three UUUUU sequences. We have shown that the h1ARE interacts with heterogeneous nuclear ribonucleop...

journal_title：Virus research

authors： Sokolowski M,Schwartz S

更新日期：2001-03-01 00:00:00

abstract：:Recent evidence has accumulated which definitively shows that chemokine receptors CCR5 and CXCR4 play an essential role as coreceptors for human immunodeficiency virus type 1 (HIV-1) infection. Flow cytometric analysis permitted us to detect CD38, a surface marker of early differentiation, as well as activation of T c...

journal_title：Virus research

authors： Horikoshi H,Kinomoto M,Sasao F,Mukai T,Luftig RB,Ikuta K

更新日期：2001-01-01 00:00:00

abstract：:An account is given of progress during the last 30 years in knowledge of the epidemiology of diseases caused by aphid-borne viruses in seed potato production areas of northern Europe. During this period, Potato leafroll virus (PLRV) and strains of Potato virus Y (PVY(O), PVY(N)) were consistently the most prevalent an...

journal_title：Virus research

authors： Robert Y,Woodford JA,Ducray-Bourdin DG

更新日期：2000-11-01 00:00:00

abstract：:The mild climate of the Salinas Valley, CA lends itself well to a diverse agricultural industry. However, the diversity of weeds, crops and insect and fungal vectors also provide favorable conditions for plant virus disease development. This paper considers the incidence and management of several plant viruses that ha...

journal_title：Virus research

authors： Wisler GC,Duffus JE

更新日期：2000-11-01 00:00:00

abstract：:The full-size NS5A (NS5A-F) of hepatitis C virus is localized in the cytoplasm despite the presence of a functional nuclear localization signal (NLS) in its C-terminal region (amino acids (aa) 354-362). In the present study, we demonstrated that a short stretch of sequence near the N-terminus of NS5A (aa 27-38) masked...

journal_title：Virus research

authors： Song J,Nagano-Fujii M,Wang F,Florese R,Fujita T,Ishido S,Hotta H

更新日期：2000-09-25 00:00:00

abstract：:Tick-borne encephalitis virus (TBEV) strains were isolated from ticks in Western Siberia for 12 years. Molecular hybridization of the 46 viral RNA with the TBEV cDNA and oligonucleotide probes revealed differences between the Siberian and Far Eastern strains. A comparison of the viral E gene fragment nucleotide sequen...

journal_title：Virus research

authors： Bakhvalova VN,Rar VA,Tkachev SE,Matveev VA,Matveev LE,Karavanov AS,Dobrotvorsky AK,Morozova OV

更新日期：2000-09-01 00:00:00

abstract：:The fusion (F) glycoprotein of respiratory syncytial virus (RSV) is synthesized as a nonfusogenic precursor protein (F(0)), which during its migration to the cell surface is activated by cleavage into the disulfide-linked F(1) and F(2) subunits. In the present study, soluble secreted human furin produced by a recombin...

journal_title：Virus research

authors： Bolt G,Pedersen LO,Birkeslund HH

更新日期：2000-06-01 00:00:00

abstract：:A 50-kDa protein that binds to viral particles in solid-phase assays and that is recognized by anti-idiotypic antibodies made against anti-viral glycoproteins G1/G2 (anti-Ids) has been proposed as a receptor candidate for tomato spotted wilt tospovirus (TSWV) in its main thrips vector, Frankliniella occidentalis Perga...

journal_title：Virus research

authors： Medeiros RB,Ullman DE,Sherwood JL,German TL

更新日期：2000-04-01 00:00:00

abstract：:Friesian calves were infected with one of three isolates of bovine viral diarrhoea virus (BVDV) and used to establish parameters for an in vitro model of BVDV-reactive T-cell responses in cattle. The study assessed virus clearance, seroconversion, maturation of lymphoproliferative responses (both during and following ...

journal_title：Virus research

authors： Collen T,Morrison WI

更新日期：2000-03-01 00:00:00

abstract：:RNA species of plant tripartite RNA viruses show distinct translational activities in vitro when the viral RNA concentration is high. However, it is not known what causes the differential translation of virion RNAs. Using an in vitro wheat germ translation system, we investigated the translation efficiencies and compe...

journal_title：Virus research

authors： Kwon CS,Chung WI

更新日期：2000-02-01 00:00:00

abstract：:To identify the parts of retroviral integrase that interact with its DNA substrates, we compared the patterns of target site usage by chimeric enzymes and protein fragments in assays that reveal integrase's non-specific nuclease activities. The central region of 12 chimeric proteins between the human immunodeficiency ...

journal_title：Virus research

authors： Katzman M,Sudol M,Pufnock JS,Zeto S,Skinner LM

更新日期：2000-01-01 00:00:00

abstract：:Persistent infections with mumps virus were established in human B-lymphoid cell line Akata and in the human chronic myelogenous leukaemia cell line K562. Even after IFN treatment a drastic decrease in STAT-1alpha (signal transducers and activators of transcription-1alpha), STAT-2 and p48 (ISGF-3gamma: IFN-stimulated ...

journal_title：Virus research

authors： Fujii N,Yokosawa N,Shirakawa S

更新日期：1999-12-15 00:00:00

abstract：:The baculovirus late expression factor 2 (LEF-2) is involved in DNA replication, and most likely function as a primase processivity factor. Lef-2 genes have been found in multinucleocapsid nucleopolyhedroviruses (MNPVs) and in granuloviruses (GVs), but not yet in single-nucleocapsid NPV (SNPV). Here, a lef-2 gene homo...

journal_title：Virus research

authors： Chen X,Ijkel WF,Dominy C,de Andrade Zanotto PM,Hashimoto Y,Faktor O,Hayakawa T,Wang CH,Prekumar A,Mathavan S,Krell PJ,Hu Z,Vlak JM

更新日期：1999-12-01 00:00:00

abstract：:Human torovirus (HTV) and Breda virus (BRV), members of the genus torovirus in the family Coronaviridae, are established infectious agents of humans and cattle, respectively. The hemagglutinin-esterase (HE) gene of Breda virus serotype 2 (BRV-2) has been identified and the nucleotide sequence for BRV serotype 1 (BRV-1...

journal_title：Virus research

authors： Duckmanton L,Tellier R,Richardson C,Petric M

更新日期：1999-11-01 00:00:00